Publications

PUBLICATIONS

Research Articles

Stevens EM, Vladar EK, Alanin MC, Christensen ST, von Buchwald C, Milla C. Ciliary Localization of the Intraflagellar Transport Protein IFT88 Is Disrupted in Cystic Fibrosis. Am J Respir Cell Mol Biol. 2020 Jan;62(1):120-123. doi: 10.1165/rcmb.2018-0287LE. PMID: 31891309.

Lang UE, Torres R, Cheung C, Vladar EK, McCalmont TH, Kim J, Judson-Torres RL. Ciliation Index Is a Useful Diagnostic Tool in Challenging Spitzoid Melanocytic Neoplasms. J Invest Dermatol. 2020 Jul;140(7):1401-1409.e2. doi: 10.1016/j.jid.2019.11.028. Epub 2020 Jan 22. PMID: 31978411

Montgomery MT, Sajuthi SP, Cho SH, Everman JL, Rios CL, Goldfarbmuren KC, Jackson ND, Saef B, Cromie M, Eng C, Medina V, Elhawary JR, Oh SS, Rodriguez- Santana J, Vladar EK, Burchard EG, Seibold MA. Genome-Wide Analysis Reveals Mucociliary Remodeling of the Nasal Airway Epithelium Induced by Urban PM2.5. Am J Respir Cell Mol Biol. 2020 Aug;63(2):172-184. doi: 10.1165/rcmb.2019-0454OC. PMID: 32275839; PMCID: PMC7397762

Goldfarbmuren KC, Jackson ND, Sajuthi SP, Dyjack N, Li KS, Rios CL, Plender EG, Montgomery MT, Everman JL, Bratcher PE, Vladar EK, Seibold MA. Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium. Nat Commun. 2020 May 19;11(1):2485. doi: 10.1038/s41467-020-16239-z. PMID: 32427931; PMCID: PMC7237663

Aros CJ, Vijayaraj P, Pantoja CJ, Bisht B, Meneses LK, Sandlin JM, Tse JA, Chen MW, Purkayastha A, Shia DW, Sucre JMS, Rickabaugh TM, Vladar EK, Paul MK, Gomperts BN. Distinct Spatiotemporally Dynamic Wnt-Secreting Niches Regulate Proximal Airway Regeneration and Aging. Cell Stem Cell. 2020 Sep 3;27(3):413-429.e4. doi: 10.1016/j.stem.2020.06.019. Epub 2020 Jul 27. PMID: 32721381; PMCID: PMC7484054

Beswick DM, Humphries SM, Balkissoon CD, Vladar EK, Ramakrishnan VR, Lynch DA, Taylor-Cousar JL. Machine learning evaluates improvement in sinus computed tomography opacification with CFTR modulator therapy. Int Forum Allergy Rhinol. 2020 Nov 2. doi: 10.1002/alr.22722. Epub ahead of print. PMID: 33140564

Smith P, Godde N, Rubio S, Tekeste M, VLADAR EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L. VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland. (2019) Sci Rep. May 8;9(1):7079. PMID: 31068622

Everman JL, Sajuthi S, Saef B, Rios C, Stoner AM, Numata M, Hu D, Eng C, Oh S, Rodriguez-Santana J, VLADAR EK, Voelker DR, Burchard EG, Seibold MA. Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations. (2019) J Allergy Clin Immunol. Mar 29. PMID: 30930175

VLADAR EK, Stratton MB, Saal ML, Salazar-De Simone G, Wang X, Wolgemuth D, Stearns T, Axelrod JD. Cyclin-dependent kinase control of motile ciliogenesis. (2018) Elife. Aug 28;7. PMID: 30152757

Kunimoto K, Bayly RD, VLADAR EK, Vonderfecht T, Gallagher A and Axelrod JD. Disruption of core planar cell polarity signaling regulates renal tubule morphogenesis but is not cystogenic. (2017) Current Biology, 27(20):3120-3131. PMID: 29033332

Boescke R*, VLADAR EK*, Konnecke M, Husing B, Linke R, Reiling N, Axelrod JD, Nayak JV and Wollenberg B. Wnt signaling in chronic rhinosinusitis with nasal polyps. (2017) American Journal of Respiratory Cell and Molecular Biology, 56(5):575-584. PMID: 28059551 *co-first authors

VLADAR EK, Nayak JV, Milla CE and Axelrod JD. Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation. (2016) Journal of Clinical Investigation Insight, 1(13):pii: e88027. PMID: 27570836

Gibbs BC, Damerla RR, VLADAR EK, Chatterjee B, Wan Y, Cui C, Gabriel GC, Zahid M, Yagi H, Heather Rodger-Szabo H, Axelrod JD and Lo CW. Planar cell polarity and cell migration defects associated with heart outflow tract anomalies and other structural birth defects in a Prickle1 mutant. (2016) Biology Open. 5(3):323-35. PMID: 26883626 

Lang UE, Cheung C, VLADAR EK, Swetter SM and Kim J. Loss of Primary Cilia Correlates with Cytologic Severity in Dysplastic Melanocytic Nevi. (2016) Journal of Cutaneous Pathology, 43(2):113-9. PMID: 26272818

Yuan K, Orcholski M, Panaroni C, Huang N, Jiang X, Shuffle E, Tian W, VLADAR EK, Rabinovitch M, Desai TJ, Nicolls M, Wu J and de Jesus Perez V. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. (2015) The American Journal of Pathology, 185(1):69-84. PMID: 25447046 

Klos Dehring DA, VLADAR EK, Werner ME, Mitchell JW, Hwang P and Mitchell BJ. Deuterosome Mediated Centriole Biogenesis. (2013) Developmental Cell, 27(1):103-12. PMID: 24075808 

Tan FE, VLADAR EK, Ma L, Fuentealba LC, Hoh RA, Espinosa H, Stearns T, Alvarez-Buylla A, Kintner C, Axelrod JD and Krasnow MA. Myb promotes centriole amplification and later steps of the multiciliogenesis program. (2013) Development, 140(20):4277-4286. PMID: 24048590

VLADAR EK, Bayly RD, Sangoram AM, Scott MP and Axelrod JD. Microtubules enable the planar cell polarity of airway cilia. (2012) Current Biology, 22(1):1-10. PMID: 23122850 

Stubbs JL, VLADAR EK, Axelrod JD and Kintner C. Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. (2012) Nature Cell Biology, 14(2):140-7. PMID: 22231168

Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, VLADAR EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF and El-Shanti HI. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. (2008) American Journal of Human Genetics, 83(5):572-81. PMID: 18976727

VLADAR EK and Stearns T. Molecular characterization of centriole assembly in ciliated epithelial cells. (2007) Journal of Cell Biology, 178(1):31-42. PMID: 17606865

Laurencon A, Orme CM, Peters HK, Boulton CL, VLADAR EK, Langley SA, Bakis EP, Harris DT, Harris NJ, Wayson SM, Hawley RS and Burtis KC. A large-scale screen for mutagen-sensitive loci in Drosophila. (2004) Genetics, 167(1):217-31. PMID: 15166149

Review Articles

Vladar EK, Königshoff M. Noncanonical Wnt planar cell polarity signaling in lung development and disease. Biochem Soc Trans. 2020 Feb 28;48(1):231-243. PMID: 32096543

Benam KH, VLADAR EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. (2018) Ann Am Thorac Soc. Nov;15 PMID: 30431350

VLADAR EK and Mitchell JB. It’s a family act: the geminin triplets take center stage in motile ciliogenesis. (2016) The EMBO Journal, 35(9):904-6. PMID: 27006276

VLADAR EK, Antic D and Axelrod JD. Planar cell polarity signaling: the developing cell’s compass. (2009) Cold Spring Harbor Perspectives in Biology, 1(3):a002964. PMID: 20066108 

VLADAR EK and Axelrod JD. Dishevelled links basal body docking and orientation. (2008) Trends in Cell Biology, 18(11):517-20. PMID: 18819800

Methods Chapters

VLADAR EK, Lee YL, Stearns T and Axelrod JD. Observing planar cell polarity in multiciliated airway epithelial cells. (2015) Methods in Cell Biology, 127:37-54. PMID: 25837385 

VLADAR EK and Brody SL. Analysis of ciliogenesis in primary culture mouse tracheal epithelial cells. (2013) Methods in Enzymology, 525:285-309. PMID: 23522475