Research Articles
Hara N, Raclawska DS, Morgan LE, NeeDell JC, Dao L, Kato A, Jaramillo AM, Hume PS, Holguin F, Janssen WJ, VLADAR EK, Evans CM. Requirement for Fucosyltransferase 2 in Allergic Airway Hyperreactivity and Mucus Obstruction. (2024) Am J Respir Cell Mol Biol. doi: 10.1165/rcmb.2024-0216OC. PMID: 39447136
Miller JE, Oh E, Khatiwada A, Humphries SM, Wilson A, VLADAR EK, Lynch DA, Taylor-Cousar JL and Beswick DM. Two-year impact of highly effective modulator therapy on olfactory dysfunction. (2024) Laryngoscope, 134(6):2492-2494. PMID: 38647113
Miller JE, Taylor-Cousar JL, Humphries SM, Khatiwada A, Chen H, Wilson A, VLADAR EK, Lynch DA, Li DA and Beswick DM. Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation. (2023) Int Forum Allergy Rhinol., 14(5):986-989. PMID: 38647113
Beswick DM, Khatiwada A, Miller JE, Humphries SM, Wilson A, VLADAR EK, Lynch DA and Taylor-Cousar JL. Impact of highly effective modulator therapy on chronic rhinosinusitis and health status: 2-year follow-up. (2023) J Cyst Fibros., 23(2):214-218. PMID: 37805356
Cooney RA, Saal ML, Geraci KP, Maynard C, Cleaver O, Hoang ON, Moore TT, Hwang RF, Axelrod JD and VLADAR EK. A WNT4 and DKK3 driven canonical to noncanonical Wnt signaling switch controls multiciliogenesis. (2023) Journal of Cell Science, 136(16):jcs260807. PMID: 37505110
Ozekin YH, Saal ML, Hernandez-Pineda R, Moehn K, Ordonez-Erives MA, Delgado Figueroa MF, Frazier C, Königshoff M, Bates EB* and VLADAR EK*. Intrauterine exposure to nicotine through maternal vaping disrupts embryonic lung and skeletal development. (2023) Developmental Biology, S0012-1606(23)00101-X. *co-senior, co-corresponding authors PMID: 37353105
VLADAR EK*, Kunimoto K, Rojas-Hernandez LS, Spano JM, Sellers ZM, Joo NS, Cooney RA, Axelrod JD** and Milla CE**. Notch signaling inactivation by small molecule gamma-secretase inhibitors restores the multiciliated cell population in the airway epithelium. (2023) AJP Lung, 324(6):L771-L782, *corresponding author, **co-senior authors PMID: 37039381
Numata M, Sajuthi S, Bochkov YA, Loeffler J, Everman J, VLADAR EK, Cooney RA, Reinhardt RL, Liu AH, Seibold MA, Voelker DR. Anionic Pulmonary Surfactant Lipid Treatment Inhibits Rhinovirus A Infection of the Human Airway Epithelium. (2023) Viruses, 15(3):747. PMID: 36992456
Vohwinkel CU, Burns N, Coit E, Yuan X, VLADAR EK, Sul C, Schmidt EP, Carmeliet P, Stenmark K, Nozik ES, Tuder RM, Eltzschig HK. HIF1A-dependent induction of alveolar epithelial PFKFB3 dampens acute lung injury. (2022) JCI Insight, 7(24):e157855. PMID: 36326834
Kunimoto K. Weiner AT, Axelrod JD and VLADAR EK. Distinct overlapping functions for Prickle1 and Prickle2 in the polarization of the airway epithelium. (2022) Front Cell Dev Biol., 10:976182. PMID: 36176272
Guo K, Barrett BS, Morrison JH, Mickens KL, VLADAR EK, Hasenkrug KJ, Poeschla EM and Santiago ML. Interferon resistance of emerging SARS-CoV-2 variants. (2022) Proc Natl Acad Sci USA, 119(32): e2203760119. PMID: 35867811
Kim E, Mathai SK, Stancil IT, Ma X, Hernandez-Gutierrez A, Becerra JN, Marrero-Torres E, Hennessy CE, Hatakka K, Wartchow EP, Estrella A, Huber JP, Cardwell JH, Burnham EL, Zhang Y, Evans CM, VLADAR EK, Schwartz DA, Dobrinskikh E and Yang IV. Aberrant multiciliogenesis in idiopathic pulmonary fibrosis. (2022) Am J Respir Cell Mol Biol., 67(2):188-200. PMID: 35608953
Heinzelmann K, Hu Q, Hu Y, Dobrinskikh E, Ansari M, Melo-Narváez MC, Ulke HM, Leavitt C, Mirita C, Trudeau T, Saal ML, Rice P, Gao B, Janssen WJ, Yang IV, Schiller HB, VLADAR EK, Lehmann M and Königshoff M. (2022) Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis. Eur Respir J., 59(6):2102373. PMID: 35604813
Beswick DM, Humphries SM, Miller JE, Balkissoon CD, Khatiwada A, VLADAR EK, Ramakrishnan VR, Lynch DA and Taylor-Cousar JL. Objective and patient-based measures of chronic rhinosinusitis in people with cystic fibrosis treated with highly effective modulator therapy. (2022) Int Forum Allergy Rhinol., 12(11):1435-1438. PMID: 35595546
Nick JA, Dedrick RM, Gray AL, VLADAR EK, Smith BE, Freeman KG, Malcolm KC, Epperson LE, Hasan NA, Hendrix J, Callahan K, Walton K, Vestal B, Wheeler E, Rysavy NM, Poch K, Caceres S, Lovell VK, Hisert KB, de Moura VC, Chatterjee D, De P, Weakly N, Martiniano SL, Lynch DA, Daley CL, Strong M, Jia F, Hatfull GF and Davidson RM. Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection. (2022) Cell, 185(11):1860-1874. PMID: 35568033
Sci Rep. 25;12(1):5207. PMID: 35338216
PLoS One 17(3):e0261504. PMID: 35286330
J Cyst Fibros. 21(2):e141-e147. PMID: 34598881
J Allergy Clin Immunol. 13:S0091-6749(21)02645-2. PMID: 35034774
Ann Am Thorac Soc. 19(1):12-19. PMID: 34436985
Int Forum Allergy Rhinol. 2021 Dec 15. doi: 10.1002/alr.22946. PMID: 34908251
Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Isarely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, VLADAR EK, Ryan AL, Plath K, Mahoney JE, Stripp BR, Gomperts BN. Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial states and composition. (2021) Nat. Med. 27(5):806-814. PMID: 33958799
Beswick DM, Humphries SM, Balkissoon CD, VLADAR EK, Ramakrishnan VR, Lynch DA, Taylor-Cousar JL. Machine learning evaluates improvement in sinus computed tomography opacification with CFTR modulator therapy. (2011) Int Forum Allergy Rhinol. 11(5):953-954. PMID: 33140564
Aros CJ, Vijayaraj P, Pantoja CJ, Bisht B, Meneses LK, Sandlin JM, Tse JA, CHen MW, Purkayastha A, Shia DW, Sucre JMS, Rickabaugh TM, VLADAR EK, Paul MK, Gomperts BM. Distinct spatiotemporally dyanamic Wnt-secreting niches regulate proximal airway regeneration and aging. (2020) Cell Stem Cell 27(3):413-429. PMID: 32721381
Montogmery MT, Sajuthi SP, Cho SH, Everman JL, Rios CL, Goldfarbmuren KC, Jackson ND, Saef B, Cromie M, Eng C, Medina V, Elhawary JR, Oh SS, Rodriguez-Santana J, VLADAR EK, Burchard EG, Seibold MA. Genome-wide analysis reveals mucociliary remodeling of the nasal airway epithelium induced by urban PM 2.5. (2020) Am J Respir Cell Mol Biol. 63(2):172-184. PMID: 32275839
Lang UE, Torres R, Cheung C, VLADAR EK, McCalmont TH, Kim J, Judson-Torres RL. Ciliation index is a useful diagnostic tool in challenging spitzoid melanocytic neoplasms. (2020) J Invest Dermatol. 140(7):1401-1409.e2. PMID: 31978411
Goldfarbmuren KC, Jackson ND, Sajuthi SP, Dyjack N, Li KS, Rios CL, Plender EG, Montgomery MT, Everman JL, Bratcher PE, EK, Seibold MA. Dissecting the cellular specificity of smoking effects and reconstructing lineages in the human airway epithelium. (2020) Nat Commun. 11(1):2485. PMID: 32427931
Stevens EM, VLADAR EK, Alanin MC, Christensen ST, von Buchwald C, Milla C. Ciliary Localization of the intraflagellar transport protein IFT88 is disrupted in cystic fibrosis. (2020) Am J Respir Cell Mol Biol. 62(1):120-123. PMID: 31891309
Everman JL, Sajuthi S, Saef B, Rios C, Stoner AM, Numata M, Hu D, Eng C, Oh S, Rodriguez-Santana J, VLADAR EK, Voelker DR, Burchard EG, Seibold MA. Functional genomics of CDHR3 confirms its role in HRV-C infection and childhood asthma exacerbations. (2019) J Allergy Clin Immunol. Mar 29. PMID: 30930175
Smith P, Godde N, Rubio S, Tekeste M, VLADAR EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L. VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland. (2019) Sci Rep. May 8;9(1):7079. PMID: 31068622
VLADAR EK, Stratton MB, Saal ML, Salazar-De Simone G, Wang X, Wolgemuth D, Stearns T, Axelrod JD. Cyclin-dependent kinase control of motile ciliogenesis. (2018) Elife. Aug 28;7. PMID: 30152757
Kunimoto K, Bayly RD, VLADAR EK, Vonderfecht T, Gallagher A and Axelrod JD. Disruption of core planar cell polarity signaling regulates renal tubule morphogenesis but is not cystogenic. (2017) Current Biology, 27(20):3120-3131. PMID: 29033332
Boescke R*, VLADAR EK*, Konnecke M, Husing B, Linke R, Reiling N, Axelrod JD, Nayak JV and Wollenberg B. Wnt signaling in chronic rhinosinusitis with nasal polyps. (2017) American Journal of Respiratory Cell and Molecular Biology, 56(5):575-584. PMID: 28059551 *co-first authors
VLADAR EK, Nayak JV, Milla CE and Axelrod JD. Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation. (2016) Journal of Clinical Investigation Insight, 1(13):pii: e88027. PMID: 27570836
Gibbs BC, Damerla RR, VLADAR EK, Chatterjee B, Wan Y, Cui C, Gabriel GC, Zahid M, Yagi H, Heather Rodger-Szabo H, Axelrod JD and Lo CW. Planar cell polarity and cell migration defects associated with heart outflow tract anomalies and other structural birth defects in a Prickle1 mutant. (2016) Biology Open. 5(3):323-35. PMID: 26883626
Lang UE, Cheung C, VLADAR EK, Swetter SM and Kim J. Loss of Primary Cilia Correlates with Cytologic Severity in Dysplastic Melanocytic Nevi. (2016) Journal of Cutaneous Pathology, 43(2):113-9. PMID: 26272818
Yuan K, Orcholski M, Panaroni C, Huang N, Jiang X, Shuffle E, Tian W, VLADAR EK, Rabinovitch M, Desai TJ, Nicolls M, Wu J and de Jesus Perez V. Activation of the Wnt/planar cell polarity pathway is required for pericyte recruitment during pulmonary angiogenesis. (2015) The American Journal of Pathology, 185(1):69-84. PMID: 25447046
Klos Dehring DA, VLADAR EK, Werner ME, Mitchell JW, Hwang P and Mitchell BJ. Deuterosome Mediated Centriole Biogenesis. (2013) Developmental Cell, 27(1):103-12. PMID: 24075808
Tan FE, VLADAR EK, Ma L, Fuentealba LC, Hoh RA, Espinosa H, Stearns T, Alvarez-Buylla A, Kintner C, Axelrod JD and Krasnow MA. Myb promotes centriole amplification and later steps of the multiciliogenesis program. (2013) Development, 140(20):4277-4286. PMID: 24048590
VLADAR EK, Bayly RD, Sangoram AM, Scott MP and Axelrod JD. Microtubules enable the planar cell polarity of airway cilia. (2012) Current Biology, 22(1):1-10. PMID: 23122850
Stubbs JL, VLADAR EK, Axelrod JD and Kintner C. Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. (2012) Nature Cell Biology, 14(2):140-7. PMID: 22231168
Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, VLADAR EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF and El-Shanti HI. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. (2008) American Journal of Human Genetics, 83(5):572-81. PMID: 18976727
VLADAR EK and Stearns T. Molecular characterization of centriole assembly in ciliated epithelial cells. (2007) Journal of Cell Biology, 178(1):31-42. PMID: 17606865
Laurencon A, Orme CM, Peters HK, Boulton CL, VLADAR EK, Langley SA, Bakis EP, Harris DT, Harris NJ, Wayson SM, Hawley RS and Burtis KC. A large-scale screen for mutagen-sensitive loci in Drosophila. (2004) Genetics, 167(1):217-31. PMID: 15166149
Review Articles & Editorials
Bridges JP, VLADAR EK, Kurche JS, Krivoi A, Stancil IT, Dobrinskikh E, Hu Y, Sasse SK, Lee JS, Blumhagen RZ, Yang IV, Gerber AN, Peljto AL, Evans CM, Redente EF, Riches DW, Schwartz DA. Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar (2025) J Clin Invest. 135(1):e183836. PMID: 39744946
Jaramillo AM, VLADAR EK, Holguin F, Dickey BF and Evans CM. Emerging cell and molecular targets for treating mucus hypersecretion in asthma. (2024) Allergol Int., 73(3):375-381. PMID: 38692992
Ghosh M and VLADAR EK. Extensive airway remodelling in severe COPD imparts resiliency to environmental stressors. (2024) Thorax, 79(6):491-492. PMID: 38575315
Hisert KB and VLADAR EK. Cystic fibrosis airways: does disease stem from faulty stem cells? (2023) Am J Respir Crit Care Med., 208(9):913-914. PMID: 37751560
Respiratory epithelial cell responses to SARS-CoV-2 in COVID-19. Thorax. (2022) Feb;77(2):203-209. PMID: 34404754 *co-first authors
VLADAR EK, Königshoff M. Noncanonical Wnt planar cell polarity signaling in lung development and disease. Biochem Soc Trans. (2020) Feb 28;48(1):231-243. PMID: 32096543
Benam KH, VLADAR EK, Janssen WJ, Evans CM. Mucociliary Defense: Emerging Cellular, Molecular, and Animal Models. (2018) Ann Am Thorac Soc. Nov;15 PMID: 30431350
VLADAR EK and Mitchell JB. It’s a family act: the geminin triplets take center stage in motile ciliogenesis. (2016) The EMBO Journal, 35(9):904-6. PMID: 27006276
VLADAR EK, Antic D and Axelrod JD. Planar cell polarity signaling: the developing cell’s compass. (2009) Cold Spring Harbor Perspectives in Biology, 1(3):a002964. PMID: 20066108
VLADAR EK and Axelrod JD. Dishevelled links basal body docking and orientation. (2008) Trends in Cell Biology, 18(11):517-20. PMID: 18819800
Methods Chapters
VLADAR EK, Lee YL, Stearns T and Axelrod JD. Observing planar cell polarity in multiciliated airway epithelial cells. (2015) Methods in Cell Biology, 127:37-54. PMID: 25837385
VLADAR EK and Brody SL. Analysis of ciliogenesis in primary culture mouse tracheal epithelial cells. (2013) Methods in Enzymology, 525:285-309. PMID: 23522475
Vladar Lab 